On one of my previous posts I was talking about the positive effects of cinnamon on Alzheimer’s patients. What I found is that patients with Alzheimer’s, CBGD, Parkinson’s, and PSP share a common trait; aggregation of tau proteins. In other words, they tangle or clump together which is toxic to neurons. This tangling or clumping is also known as tauopathy. Tau proteins are mainly located in the central nervous system and stabilize microtubules(these provide the transport of materials). When aggregation occurs, dementia sets in. The goal is to inhibit aggregation but what causes it is not clear and there is some controversy that tangles are a primary cause for dementia. At this point, there are differences on how tau proteins aggregate. For Alzheimers, tangles are formed by hyperphosphorylation of microtubles . (more later)While diseases like CBGD, Frontotemporal dementia, PSP(Progressive Supranuclear Palsey) and Pick’s disease are classified as Pick complex diseases because of the frontal and temporal deterioration of the brain. While Pick’s disease was once used to classify a group of syndromes, it is now more or less used to describe a certain pathology that contributes to frontotemporal dementia , others still refer to it as Pick’s disease. Diseases like Alzheimer’s seem to have a genetic link but syndromes like CBGD, PSP, and Picks disease do not.
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