On one of my previous posts I was talking about the positive effects of cinnamon on Alzheimer’s patients.  What I found is that patients with Alzheimer’s, CBGD,  Parkinson’s, and PSP  share a common trait;  aggregation of tau proteins. In other words, they tangle or clump  together which is toxic to neurons.  This tangling or clumping is also known as tauopathy.  Tau proteins are mainly located in the central nervous system and  stabilize  microtubules(these provide the transport of materials). When  aggregation occurs,  dementia sets in.   The goal is to inhibit aggregation but what causes it is not clear and there is some controversy that tangles are a primary cause for dementia. At this point, there are differences on how tau proteins aggregate.  For Alzheimers, tangles are formed by hyperphosphorylation of microtubles . (more later)While diseases like  CBGD, Frontotemporal dementia, PSP(Progressive Supranuclear Palsey) and Pick’s disease are  classified as Pick complex diseases  because of the frontal and temporal deterioration of the brain.    While Pick’s disease was once used  to classify a group of syndromes,  it is now more or less used to describe a certain pathology  that  contributes to frontotemporal dementia , others still refer to it as Pick’s disease.   Diseases like Alzheimer’s seem to have a genetic link but syndromes like CBGD, PSP, and Picks disease do not.

Fro more info:

http://www.ncbi.nlm.nih.gov/pubmed/20149808

http://www.taurx.com/tau.htm

http://en.wikipedia.org/wiki/Corticobasal_degeneration

http://en.wikipedia.org/wiki/Tauopathy

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2 responses »

  1. This actually answered my downside, thank you!

  2. Good post… Just killing some time browsing searches and found your blog. Good looking blog. I will have to bookmark the blog to come back and see what’s new. Cheers Free Modern Warfare 3!

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